At a glance
- Gonadorelin was approved by the FDA (Factrel, Lutrepulse, September 30, 1982), but the products are no longer marketed.
- PubMed lists 307 publications mentioning it, including 16 randomized controlled trials and 132 animal-only studies.
- ClinicalTrials.gov lists 16 registered studies testing it (6 active).
- FDA's adverse event system (FAERS) holds 611 reports mentioning it; 589 classified as serious. Reports do not prove causation.
Research topics
Most frequent MeSH subject headings in the latest PubMed records (English, as indexed).
Regulatory status
Drugs@FDA applications
| Application | Product | Status | First approval | Sponsor |
|---|---|---|---|---|
| NDA018123 | FACTREL | Approved, discontinued | September 30, 1982 | HIKMA |
| NDA019687 | LUTREPULSE KIT | Approved, discontinued | October 10, 1989 | FERRING |
Source: Drugs@FDA (openFDA) · verified October 30, 2026 · API query
FDA compounding safety list
Not on FDA's list of bulk drug substances that may present significant safety risks in compounding.
Source: FDA.gov — Category 2 bulk drug substances · verified October 30, 2026
Removal of a substance from a regulatory list does not mean it has been approved. A "research use only" label does not make a product safe or legal for human use.
Scientific publications
Counts are PubMed records that mention the peptide in the title or abstract. Categories overlap, and a mention is not the same as testing the peptide as a treatment. Each number opens the exact PubMed search. Effects seen in laboratory or animal studies may not occur in humans. A registered clinical trial does not show that a substance is effective or safe.
Latest publications
- Ovulation Timing After Recombinant Human Chorionic Gonadotropin, Gonadorelin, or Buserelin Under Estrus-Triggered and Fixed-Time Treatment Protocols for Artificial Insemination in Sows.
- Progesterone feedback effects on LH pulse and surge secretion in ovariectomized Bos taurus, Bos indicus and crossbred heifers.
- Peptides in urology and sexual medicine: clinical effectiveness, dosing, indications, and safety: a narrative review.
- Effects of high frequency administration of GnRH or kisspeptin on LH pulse and surge profiles in ovariectomized Bos taurus and Bos indicus heifers†.
- Recombinant bovine somatotropin at synchronization initiation, but not at embryo transfer, enhances fertility in embryo-recipient heifers: Associations with follicular, luteal, and embryonic outcomes.
- Ovarian remnant syndrome in a 2-year-old cat with inconclusive diagnostics.
- Effect of post-insemination GnRH analogue administration on pregnancy rates in repeat-breeder cows: Comparison of dosage and frequency.
- Diagnostic Usefulness of Subcutaneous Triptorelin Stimulation Testing in the Evaluation of Central Precocious Puberty in Girls.
- A new cetrorelix-based estrogen-free ovarian synchronization protocol for fixed-time artificial insemination in beef cattle.
- Increasing gonadorelin hydrochloride dose at the first GnRH of breeding Ovsynch enhances luteinizing hormone release, ovulatory response, and pregnancy in first-service lactating dairy cows.
Source: PubMed (NCBI) · verified October 30, 2026
Clinical trials
- Registered
- 16
- Active
- 6
- With posted results
- 6
Conditions studied
Show 6 more studies
| Study | Status | Phase | Start |
|---|---|---|---|
| Effects of Dietary Omega-3 Fatty Acids on Reproductive Hormones in Obese Women | Completed | N/A | Jul 2014 |
| LutrePulse Hypogonadotropic Hypogonadism | Completed | Phase 3 | April 1, 2014 |
| Estrogen Sensitivity and Ovulatory Dysfunction in Obesity | Completed | N/A | Jun 2011 |
| Reproductive Hormonal Alterations in Obesity | Completed | N/A | Jun 2010 |
| Comparative Validation of the Triptorelin Test for the Diagnosis of CPP in Girls | Completed | Phase 3 | Dec 2009 |
| Psychostimulant Abuse - Novel Treatment Approaches - 1 | Completed | Phase 1 | — |
All 16 studies on ClinicalTrials.gov ↗
Source: ClinicalTrials.gov · verified October 30, 2026
Adverse event reports
- Reports
- 611
- Serious
- 589
- With death outcome
- 41
Most reported reactions
Adverse event reports do not prove that the substance caused these effects. Side effects not listed here may still occur. Reaction terms are MedDRA terms as reported to FAERS.
Source: FDA FAERS (FAERS data as of July 30, 2026) · verified October 30, 2026 · API query
Change history
No changes since monitoring began on October 30, 2026.