At a glance
- Human chorionic gonadotropin (hCG) is an FDA-approved drug, marketed as Chorionic, Pregnyl, Ovidrel (first approval: January 15, 1974).
- PubMed lists 8,149 publications mentioning it, including 1,149 randomized controlled trials and 1,565 animal-only studies.
- ClinicalTrials.gov lists 329 registered studies testing it (36 active).
- FDA's adverse event system (FAERS) holds 3,617 reports mentioning it; 2,296 classified as serious. Reports do not prove causation.
Research topics
Most frequent MeSH subject headings in the latest PubMed records (English, as indexed).
Regulatory status
Drugs@FDA applications
| Application | Product | Status | First approval | Sponsor |
|---|---|---|---|---|
| BLA017016 | CHORIONIC GONADOTROPIN | Approved, marketed | January 15, 1974 | FERRING |
| BLA017692 | PREGNYL | Approved, marketed | October 20, 1976 | ORGANON USA LLC |
| BLA021149 | OVIDREL | Approved, marketed | September 20, 2000 | EMD SERONO |
Source: Drugs@FDA (openFDA) · verified October 30, 2026 · API query
FDA compounding safety list
Not on FDA's list of bulk drug substances that may present significant safety risks in compounding.
Source: FDA.gov — Category 2 bulk drug substances · verified October 30, 2026
Removal of a substance from a regulatory list does not mean it has been approved. A "research use only" label does not make a product safe or legal for human use.
Scientific publications
Counts are PubMed records that mention the peptide in the title or abstract. Categories overlap, and a mention is not the same as testing the peptide as a treatment. Each number opens the exact PubMed search. Effects seen in laboratory or animal studies may not occur in humans. A registered clinical trial does not show that a substance is effective or safe.
Latest publications
- Luteinizing hormone regulates seasonal steroidogenesis locally in the prostate of the muskrat (Ondatra zibethicus).
- Association between serum estradiol levels on the hCG trigger day and euploid blastocyst rate in preimplantation genetic testing cycles: a retrospective cohort study.
- Comparison of Modified Natural Cycle Versus True Natural Cycle Frozen Embryo Transfer in Terms of Clinical Pregnancy and Live Birth Outcomes: A Single-Centre Retrospective Cohort Study.
- Ovulation Timing After Recombinant Human Chorionic Gonadotropin, Gonadorelin, or Buserelin Under Estrus-Triggered and Fixed-Time Treatment Protocols for Artificial Insemination in Sows.
- Nonlinear relationship between serum LH levels on hCG trigger day and live birth rates in patients with fresh embryo transfer: a retrospective cohort study.
- Relationship Between Dominant Follicle Diameter on the hCG Trigger Day and Live Birth After Modified Natural Cycle Frozen Embryo Transfer: A Retrospective Cohort Study.
- Endometrial compaction and ongoing pregnancy in modified natural cycle frozen euploid embryo transfer: a prospective multicentre cohort study with standardized transvaginal ultrasound assessment.
- Progesterone levels on hCG trigger day and neonatal outcomes in fresh embryo transfers: a retrospective threshold analysis of GnRH antagonist versus agonist long protocols.
- Outcomes with intracytoplasmic sperm injection using fresh vs. frozen elongated spermatids from microsurgical testicular sperm extraction.
- The hidden risk: inadvertent pregnancies in random start ovarian stimulation protocols and ovarian hyperstimulation syndrome.
Source: PubMed (NCBI) · verified October 30, 2026
Clinical trials
- Registered
- 329
- Active
- 36
- With posted results
- 44
Conditions studied
Show 40 more studies
All 329 studies on ClinicalTrials.gov ↗
Source: ClinicalTrials.gov · verified October 30, 2026
Adverse event reports
- Reports
- 3,617
- Serious
- 2,296
- With death outcome
- 57
Most reported reactions
Adverse event reports do not prove that the substance caused these effects. Side effects not listed here may still occur. Reaction terms are MedDRA terms as reported to FAERS.
Source: FDA FAERS (FAERS data as of July 30, 2026) · verified October 30, 2026 · API query
FDA prescribing information
Official US prescribing information. Dosing sections are intentionally not shown.
Source: DailyMed / openFDA
Change history
No changes since monitoring began on October 30, 2026.